Equol Supplement (S-Equol) – Premium Fermentation-Based Raw Material for Women’s Wellness Formulations
Shaanxi Zhonghong Investment Technology Co., Ltd. supplies high-grade S-Equol for brands seeking a stable, research-backed ingredient for women’s wellness, healthy aging, and functional nutrition. Our Equol ingredient is produced using precision-controlled fermentation, resulting in a clean, consistent, and high-purity raw material suitable for capsules, tablets, gummies, and beauty-from-within applications.
Each batch is manufactured under ISO, HACCP, and GMP-compliant facilities, supported by third-party analytical testing and complete traceability documentation. This product page is designed specifically for international B2B purchasers, contract manufacturers, and R&D formulators who require transparent specifications, quality evidence, and regulatory-aligned messaging.
1. Product Overview
A fermentation-derived S-Equol ingredient offering high purity, clean sensory characteristics, and compatibility with multiple dosage formats. Suitable for nutraceutical, healthy-aging, and cosmetic product development.
2. Product Summary Table
| Item | Description |
|---|---|
| Product Name | S-Equol / Equol Supplement |
| Purity | ≥98% (HPLC) or commercial 90% grade |
| Solubility | Standard, water-soluble, or oil-dispersible |
| Appearance | Off-white to pale-yellow crystalline powder |
| Source | Fermentation of non-GMO soy isoflavones |
| CAS Number | 531-95-3 |
| Production Standard | ISO / HACCP / GMP |
| Supply Capacity | 3–5 MT monthly |
| MOQ | 1 kg (sample), 25 kg (commercial batch) |
| Shelf Life | 24 months |
| Packaging | 1 kg foil bag / 25 kg drum |
3. Scientific Source & Quality Assurance
3.1 Raw Material Traceability
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Non-GMO soy isoflavone sourcing (verified suppliers + batch origin records).
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Documented material flow from isoflavone extraction → daidzein → microbial bioconversion → crystallization.
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Full traceability files available for regulatory audits.
3.2 Production Under ISO / HACCP / GMP
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Controlled fermentation using validated microbial strains.
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GMP-certified cleanrooms with environmental monitoring.
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HACCP hazard analysis applied from raw materials to packaging.
3.3 Third-Party Testing
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HPLC – assay, identity, purity.
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UV-Vis – auxiliary quality confirmation.
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ICP-MS – heavy metals.
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GC-MS – pesticide residue screening.
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Microbial – TPC, yeast/mold, pathogens.
3.4 Quality Documentation Available
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COA
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HPLC chromatogram
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ICP-MS report
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GC-MS pesticide report
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Microbial analysis
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MSDS & Allergen Statement
4. Technical Definition
S-Equol is a chiral isoflavone metabolite produced from daidzein through precise microbial biotransformation. The S-enantiomer is the primary target for dietary supplementation due to its selective receptor affinity and favorable stability profile. Its clean sensory characteristics allow easy incorporation into oral and topical formulations.
5. Manufacturing & Quality Control
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Strain selection & fermentation: Strict control of time, oxygen, pH, and nutrient supply.
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Biotransformation monitoring: HPLC-based reaction tracking.
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Purification system: Multi-step chromatography + crystallization.
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Final milling: Achieves consistent particle size for uniform blending.
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Release testing: Every batch validated before shipment.
6. Production Process Flow
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Non-GMO soy isoflavone extraction
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Daidzein isolation
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Fermentation with selected strains
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Biotransformation to S-Equol
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Purification via chromatography
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Crystallization & drying
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Sieving & milling
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Packaging under GMP
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Final COA issued
7. Functional Properties (Non-medical)
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Highly active fermentation-derived isoflavone metabolite
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Selective ER-β affinity (reported in peer-reviewed research)
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Stable across typical supplement manufacturing temperatures
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Suitable for beauty-from-within & women’s wellness formulations
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High purity enabling lower inclusion levels
8. Usage Guidelines (Industry Practice)
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Nutraceuticals: 5–20 mg/day in commercial formulas
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Beauty-from-within: works well with peptides, vitamins, probiotics
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Cosmetics: recommended 0.1–1% in serums and creams
Formulators must verify regulatory requirements in each target market.
9. Formulation Recommendations
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Protect from high-temperature extrusion processes.
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Consider microencapsulation for enhanced stability.
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Combine with collagen peptides, Pueraria extracts, probiotics, or vitamin blends for multi-functional concepts.
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Use the water-soluble grade for beverages and sticks.
10. COA Specification Template
A. Identification & Assay
| Item | Specification | Method |
|---|---|---|
| Description | Off-white powder | Visual |
| S-Equol Assay | ≥98% or ≥90% | HPLC |
| Appearance of Solution | Clear | USP |
| Loss on Drying | ≤2.0% | USP |
| Residue on Ignition | ≤0.2% | USP |
B. Heavy Metals
| Name | Limit | Method |
|---|---|---|
| Lead | ≤0.5 ppm | ICP-MS |
| Arsenic | ≤1 ppm | ICP-MS |
| Cadmium | ≤0.5 ppm | ICP-MS |
| Mercury | ≤0.1 ppm | ICP-MS |
| Total Heavy Metals | ≤10 ppm | ICP-MS |
C. Pesticide Residues
| Category | Specification | Method |
|---|---|---|
| Organochlorine | Conforms to USP | GC-MS |
| Organophosphate | Conforms | GC-MS |
| Pyrethroid Panel | Conforms | GC-MS |
| EU/USP Multi-screen | Pass | GC-MS |
D. Microbiology
| Test | Limit | Method |
|---|---|---|
| TPC | ≤1,000 CFU/g | USP |
| Yeast & Mold | ≤100 CFU/g | USP |
| E. coli | Negative | USP |
| Salmonella | Negative | USP |
| Staphylococcus aureus | Negative | USP |
11. Storage & Shelf Life
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Store in airtight, light-protected containers.
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Ideal storage temperature: below 25°C.
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Avoid humidity exposure.
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Shelf life: 24 months in original packaging.
12. Packaging, Transport & MOQ
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Packaging: 1 kg aluminum bag; 25 kg food-grade drum
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Transport: palletized export packaging; optional temperature-controlled shipment
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MOQ: 1 kg R&D sample; 25 kg for standard orders
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Lead Time: 3–7 business days
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Samples: 10–20 g available for testing
13. Application Industries
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Nutraceuticals / dietary supplements
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Women’s healthy aging formulations
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Functional beverages
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Beauty-from-within nutrition
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Topical skincare
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R&D and clinical nutrition projects
14. Application Scenarios
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Capsules and tablets
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Gummies and soft chews
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Oral powders & sachets
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RTD beverages (water-soluble grade)
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Anti-aging serums & creams
15. Factory Competence & Certifications
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10+ years of fermentation & botanical ingredient production
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ISO9001, HACCP, GMP-certified workshops
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Dedicated R&D lab with HPLC, GC, UV, and microbiology suite
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Consistent supply capacity supporting global OEM brands
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International documentation support for customs & regulatory filing
16. Frequently Asked Questions (FAQ)
(1) Do you offer customized purity or solubility?
Yes. We provide ≥98% high-purity grade, ≥90% standard grade, plus water-soluble and oil-dispersible versions.
(2) Can this material be used in cosmetics?
Yes. Our cosmetic-grade S-Equol is suitable for topical use, subject to local regulatory guidelines.
(3) Do you provide regulatory support?
We offer COA, MSDS, Non-GMO, Allergen Statement, Halal, Kosher, and technical data sheets.
(4) How do you ensure consistent quality?
Each batch undergoes identity, purity, heavy metal, pesticide, and microbial testing.
(5) Do you support OEM/Private Label projects?
Yes. We provide formulation guidance and contract manufacturing services.
17. References (Scientific & Regulatory Sources)
(1) PubMed – Equol Research Database
https://pubmed.ncbi.nlm.nih.gov
(2) NIH ODS – Isoflavone Scientific Resources
https://ods.od.nih.gov
(3) FDA – GRAS Notices related to soy components
https://www.fda.gov
(4) EFSA – Isoflavone Scientific Opinions
https://www.efsa.europa.eu
(5) Peer-reviewed studies on equol metabolism, receptor selectivity, and fermentation-based production (available upon request).
